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Site-specific hydrolysis and alcoholysis of human immunodeficiency virus DNA termini mediated by the viral integrase protein.

Before integration of the human immunodeficiency virus (HIV) DNA, two nucleotides are removed from the 3' ends of the viral DNA by the integrase (IN) protein. We studied the chemistry of this reaction, and found that IN mediates site-specific hydrolysis of a phosphodiester bond, resulting in release...

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Udgivet i:Nucleic Acids Res
Principais autores: Vink, C, Yeheskiely, E, van der Marel, G A, van Boom, J H, Plasterk, R H
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1991
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329296/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1662361/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/19.24.6691
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