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Site-specific hydrolysis and alcoholysis of human immunodeficiency virus DNA termini mediated by the viral integrase protein.

Before integration of the human immunodeficiency virus (HIV) DNA, two nucleotides are removed from the 3' ends of the viral DNA by the integrase (IN) protein. We studied the chemistry of this reaction, and found that IN mediates site-specific hydrolysis of a phosphodiester bond, resulting in re...

詳細記述

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書誌詳細
主要な著者: Vink, C, Yeheskiely, E, van der Marel, G A, van Boom, J H, Plasterk, R H
フォーマット: Artigo
言語:Inglês
出版事項: 1991
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC329296/
https://ncbi.nlm.nih.gov/pubmed/1662361
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