APOE Genotype Results in Differential Effects on the Peripheral Clearance of Amyloid-β(42) in APOE Knock-in and Knock-out Mice

The ε4 allele of apolipoprotein E (APOE) is currently the major genetic risk factor identified for Alzheimer’s disease (AD). Previous in vivo data from our laboratory has demonstrated that amyloid-β (Aβ) is rapidly removed from the plasma by the liver and kidney and that the rate of its clearance is...

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Detalhes bibliográficos
Main Authors: Sharman, Matthew J., Morici, Michael, Hone, Eugene, Berger, Tamar, Taddei, Kevin, Martins, Ian J., Lim, Wei Ling F., Singh, Sajla, Wenk, Markus R., Ghiso, Jorge, Buxbaum, Joseph D., Gandy, Sam, Martins, Ralph N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3292909/
https://ncbi.nlm.nih.gov/pubmed/20555142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2010-100141
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