Reprogrammed keratinocytes from elderly type 2 diabetes patients suppress senescence genes to acquire induced pluripotency

Nuclear reprogramming enables patient-specific derivation of induced pluripotent stem (iPS) cells from adult tissue. Yet, iPS generation from patients with type 2 diabetes (T2D) has not been demonstrated. Here, we report reproducible iPS derivation of epidermal keratinocytes (HK) from elderly T2D pa...

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Detalhes bibliográficos
Main Authors: Ohmine, Seiga, Squillace, Karen A., Hartjes, Katherine A., Deeds, Michael C., Armstrong, Adam S., Thatava, Tayaramma, Sakuma, Toshie, Terzic, Andre, Kudva, Yogish, Ikeda, Yasuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3292906/
https://ncbi.nlm.nih.gov/pubmed/22308265
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