TP53 codon 72 polymorphism affects accumulation of mtDNA damage in human cells

Human TP53 gene is characterised by a polymorphism at codon 72 leading to an Arginine-to-Proline (R/P) substitution. The two resulting p53 isoforms have a different subcellular localisation after stress (more nuclear or more mitochondrial for the P or R isoform, respectively). p53P72 variant is more...

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Detalhes bibliográficos
Main Authors: Altilia, Serena, Santoro, Aurelia, Malagoli, Davide, Lanzarini, Catia, Álvarez, Josué Adolfo Ballesteros, Galazzo, Gianluca, Porter, Donald Carl, Crocco, Paolina, Rose, Giuseppina, Passarino, Giuseppe, Roninson, Igor Boris, Franceschi, Claudio, Salvioli, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3292903/
https://ncbi.nlm.nih.gov/pubmed/22289634
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