O-GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver

OBJECTIVE: Carbohydrate-responsive element–binding protein (ChREBP) is a key transcription factor that mediates the effects of glucose on glycolytic and lipogenic genes in the liver. We have previously reported that liver-specific inhibition of ChREBP prevents hepatic steatosis in ob/ob mice by spec...

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Hlavní autoři: Guinez, Céline, Filhoulaud, Gaëlle, Rayah-Benhamed, Fadila, Marmier, Solenne, Dubuquoy, Céline, Dentin, Renaud, Moldes, Marthe, Burnol, Anne-Françoise, Yang, Xiaoyong, Lefebvre, Tony, Girard, Jean, Postic, Catherine
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2011
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3292313/
https://ncbi.nlm.nih.gov/pubmed/21471514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0452
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