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Structural Basis for Differential Insertion Kinetics of dNMPs Opposite a Difluorotoluene Nucleotide Residue
We have recently challenged the widely held view that 2,4-difluorotoluene (dF) is a non-polar isosteric analogue of the nucleotide dT, incapable of forming hydrogen bonds (HBs). To gain a further understanding for the kinetic preference that favors dAMP insertion opposite a templating dF, a result t...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3292180/ https://ncbi.nlm.nih.gov/pubmed/22304682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2016487 |
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