MicroRNA-1826 directly targets beta-catenin (CTNNB1) and MEK1 (MAP2K1) in VHL-inactivated renal cancer

The aim of this project is to identify new therapeutic microRNAs (miRNAs) for von Hippel-Lindau (VHL)-inactivated renal cancer cells. We initially identified several potential miRNAs targeting CTNNB1 and MEK1 using several targets scan algorithms. Only miR-1826 was found to target CTNNB1 and MEK1. T...

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Hlavní autoři: Hirata, Hiroshi, Hinoda, Yuji, Ueno, Koji, Nakajima, Koichi, Ishii, Nobuhisa, Dahiya, Rajvir
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Biology, Genetics and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291860/
https://ncbi.nlm.nih.gov/pubmed/22180573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr302
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