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Telomere length is associated with disease severity and declines with age in dyskeratosis congenita

BACKGROUND: Dyskeratosis congenita is a cancer-prone bone marrow failure syndrome caused by aberrations in telomere biology. DESIGN AND METHODS: We studied 65 patients with dyskeratosis congenita and 127 unaffected relatives. Telomere length was measured by automated multicolor flow fluorescence in...

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Detalhes bibliográficos
Main Authors: Alter, Blanche P., Rosenberg, Philip S., Giri, Neelam, Baerlocher, Gabriela M., Lansdorp, Peter M., Savage, Sharon A.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291588/
https://ncbi.nlm.nih.gov/pubmed/22058220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.055269
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