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Exploring the Evolution of Novel Enzyme Functions within Structurally Defined Protein Superfamilies

In order to understand the evolution of enzyme reactions and to gain an overview of biological catalysis we have combined sequence and structural data to generate phylogenetic trees in an analysis of 276 structurally defined enzyme superfamilies, and used these to study how enzyme functions have evo...

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Detalhes bibliográficos
Main Authors: Furnham, Nicholas, Sillitoe, Ian, Holliday, Gemma L., Cuff, Alison L., Laskowski, Roman A., Orengo, Christine A., Thornton, Janet M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291543/
https://ncbi.nlm.nih.gov/pubmed/22396634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002403
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