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Covariate Pharmacokinetic Model Building in Oncology and its Potential Clinical Relevance
When modeling pharmacokinetic (PK) data, identifying covariates is important in explaining interindividual variability, and thus increasing the predictive value of the model. Nonlinear mixed-effects modeling with stepwise covariate modeling is frequently used to build structural covariate models, an...
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Springer US
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3291194/ https://ncbi.nlm.nih.gov/pubmed/22274748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9320-2 |
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