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Using a Low Denaturant Model to Explore the Conformational Features of Translocation-Active SecA(†)
The SecA molecular nanomachine in bacteria uses energy from ATP hydrolysis to drive posttranslational secretion of pre-proteins through the SecYEG translocon. Cytosolic SecA exists in a dimeric, ‘closed’ state with relatively low ATPase activity. After binding to the translocon, SecA undergoes major...
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| Glavni autori: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3290997/ https://ncbi.nlm.nih.gov/pubmed/22304380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201793e |
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