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Using a Low Denaturant Model to Explore the Conformational Features of Translocation-Active SecA(†)

The SecA molecular nanomachine in bacteria uses energy from ATP hydrolysis to drive posttranslational secretion of pre-proteins through the SecYEG translocon. Cytosolic SecA exists in a dimeric, ‘closed’ state with relatively low ATPase activity. After binding to the translocon, SecA undergoes major...

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Autori principali: Maki, Jenny L., Krishnan, Beena, Gierasch, Lila M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290997/
https://ncbi.nlm.nih.gov/pubmed/22304380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201793e
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