Core Site-Moiety Maps Reveal Inhibitors and Binding Mechanisms of Orthologous Proteins by Screening Compound Libraries

Members of protein families often share conserved structural subsites for interaction with chemically similar moieties despite low sequence identity. We propose a core site-moiety map of multiple proteins (called CoreSiMMap) to discover inhibitors and mechanisms by profiling subsite-moiety interacti...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Hsu, Kai-Cheng, Cheng, Wen-Chi, Chen, Yen-Fu, Wang, Hung-Jung, Li, Ling-Ting, Wang, Wen-Ching, Yang, Jinn-Moon
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290551/
https://ncbi.nlm.nih.gov/pubmed/22393385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032142
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi