Core Site-Moiety Maps Reveal Inhibitors and Binding Mechanisms of Orthologous Proteins by Screening Compound Libraries

Members of protein families often share conserved structural subsites for interaction with chemically similar moieties despite low sequence identity. We propose a core site-moiety map of multiple proteins (called CoreSiMMap) to discover inhibitors and mechanisms by profiling subsite-moiety interacti...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Hsu, Kai-Cheng, Cheng, Wen-Chi, Chen, Yen-Fu, Wang, Hung-Jung, Li, Ling-Ting, Wang, Wen-Ching, Yang, Jinn-Moon
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290551/
https://ncbi.nlm.nih.gov/pubmed/22393385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032142
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares