Core Site-Moiety Maps Reveal Inhibitors and Binding Mechanisms of Orthologous Proteins by Screening Compound Libraries

Members of protein families often share conserved structural subsites for interaction with chemically similar moieties despite low sequence identity. We propose a core site-moiety map of multiple proteins (called CoreSiMMap) to discover inhibitors and mechanisms by profiling subsite-moiety interacti...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Hsu, Kai-Cheng, Cheng, Wen-Chi, Chen, Yen-Fu, Wang, Hung-Jung, Li, Ling-Ting, Wang, Wen-Ching, Yang, Jinn-Moon
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2012
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290551/
https://ncbi.nlm.nih.gov/pubmed/22393385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032142
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