Core Site-Moiety Maps Reveal Inhibitors and Binding Mechanisms of Orthologous Proteins by Screening Compound Libraries

Members of protein families often share conserved structural subsites for interaction with chemically similar moieties despite low sequence identity. We propose a core site-moiety map of multiple proteins (called CoreSiMMap) to discover inhibitors and mechanisms by profiling subsite-moiety interacti...

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Bibliografiske detaljer
Main Authors: Hsu, Kai-Cheng, Cheng, Wen-Chi, Chen, Yen-Fu, Wang, Hung-Jung, Li, Ling-Ting, Wang, Wen-Ching, Yang, Jinn-Moon
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290551/
https://ncbi.nlm.nih.gov/pubmed/22393385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032142
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