Allele-specific siRNA knockdown as a personalized treatment strategy for vascular Ehlers-Danlos syndrome in human fibroblasts

The vascular type of the Ehlers-Danlos syndrome (vEDS) is caused by dominant-negative mutations in the procollagen type III (COL3A1) gene. Patients with this autosomal dominant disorder have a shortened life expectancy due to complications from ruptured vessels or hollow organs. We tested the effect...

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Detalhes bibliográficos
Main Authors: Müller, Gerd A., Hansen, Uwe, Xu, Zhi, Griswold, Benjamin, Talan, Mark I., McDonnell, Nazli B., Briest, Wilfried
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2012
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290443/
https://ncbi.nlm.nih.gov/pubmed/22038052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-182162
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