Estradiol down regulates the binding activity of an avian vitellogenin gene repressor (MDBP-2) and triggers a gradual demethylation of the mCpG pair of its DNA binding site.

A negative regulating protein (MDBP-2) from rooster liver nuclear extracts binds preferentially to a methylated promoter region 5'TTCACCTTmCGCTATGAGGGGGATCATACTGG3' of the avian vitellogenin II gene (Nucleic Acids Res. 19, 1029-1034, 1991). Treatment of adult and immature roosters with est...

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Autores principales: Jost, J P, Saluz, H P, Pawlak, A
Formato: Artigo
Lenguaje:Inglês
Publicado: 1991
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC328989/
https://ncbi.nlm.nih.gov/pubmed/1945854
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