The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk

Proteins containing a caveolin-binding domain (CBD), such as the Rho-GTPases, can interact with caveolin-1 (Cav1) through its caveolin scaffold domain. Rho-GTPases are important regulators of p130(Cas), which is crucial for both normal cell migration and Src kinase-mediated metastasis of cancer cell...

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Detalhes bibliográficos
Main Authors: Arpaia, E, Blaser, H, Quintela-Fandino, M, Duncan, G, Leong, H S, Ablack, A, Nambiar, S C, Lind, E F, Silvester, J, Fleming, C K, Rufini, A, Tusche, M W, Brüstle, A, Ohashi, P S, Lewis, J D, Mak, T W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289793/
https://ncbi.nlm.nih.gov/pubmed/21765460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.288
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