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Frequent Heterogeneous Missense Mutations of GGAP2 in Prostate Cancer: Implications for Tumor Biology, Clonality and Mutation Analysis

Prostate cancer is the most common visceral malignancy in Western men and a major cause of cancer deaths. Increased activation of the AKT and NFkB pathways have been identified as critical steps in prostate cancer initiation and progression. GGAP2 (GTP-binding and GTPase activating protein 2) is a m...

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Hlavní autoři: Cai, Yi, Wang, Jianghua, Ren, Chengxi, Ittmann, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289671/
https://ncbi.nlm.nih.gov/pubmed/22389719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032708
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