Asynchronous Ca(2)(+) current conducted by voltage-gated Ca(2+) (Ca(V))-2.1 and Ca(V)2.2 channels and its implications for asynchronous neurotransmitter release

We have identified an asynchronously activated Ca(2+) current through voltage-gated Ca(2+) (Ca(V))-2.1 and Ca(V)2.2 channels, which conduct P/Q- and N-type Ca(2+) currents that initiate neurotransmitter release. In nonneuronal cells expressing Ca(V)2.1 or Ca(V)2.2 channels and in hippocampal neurons...

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Main Authors: Few, Alexandra P., Nanou, Evanthia, Watari, Hirofumi, Sullivan, Jane M., Scheuer, Todd, Catterall, William A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2012
Ábhair:
PNAS Plus
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289374/
https://ncbi.nlm.nih.gov/pubmed/22308469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121103109
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