Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA

Deamination of nucleobases in DNA and RNA results in the formation of xanthine (X), hypoxanthine (I), oxanine, and uracil, all of which are miscoding and mutagenic in DNA and can interfere with RNA editing and function. Among many forms of nucleic acid damage, deamination arises from several unrelat...

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Detalhes bibliográficos
Main Authors: Pang, Bo, McFaline, Jose L., Burgis, Nicholas E., Dong, Min, Taghizadeh, Koli, Sullivan, Matthew R., Elmquist, C. Eric, Cunningham, Richard P., Dedon, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289290/
https://ncbi.nlm.nih.gov/pubmed/22308425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118455109
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