Ultra-low Dose of Mycobacterium tuberculosis Aerosol Creates Partial Infection in Mice

A murine low-dose (LD) aerosol model is commonly used to test tuberculosis vaccines. Doses of 50-400 CFU (24-hour lung CFU) infect 100% of exposed mice. The LD model measures progression from infection to disease based on organ CFU at defined time points. To mimic natural exposure, we exposed mice t...

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Autori principali: Saini, Divey, Hopkins, Gregory W., Seay, Sarah A., Chen, Ching-Ju, Perley, Casey C., Click, Eva M., Frothingham, Richard
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288716/
https://ncbi.nlm.nih.gov/pubmed/22197183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tube.2011.11.007
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