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A Rationally Designed Pyrrolysyl-tRNA Synthetase Mutant Has a Broad Substrate Spectrum

Together with [Formula: see text] , a rationally designed pyrrolysyl-tRNA synthetase mutant N346A/C348A has been successfully used for the genetic incorporation of a variety of phenylalanine derivatives with large para substitutes into superfolder green fluorescent protein at an amber mutation site...

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Autors principals: Wang, Yane-Shih, Fang, Xinqiang, Wallace, Ashley L., Wu, Bo, Liu, Wenshe R.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288562/
https://ncbi.nlm.nih.gov/pubmed/22289053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja211972x
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