Combining the Multi-Targeted Tyrosine Kinase Inhibitor Vandetanib with the Anti-Estrogen Fulvestrant Enhances its Anti-tumor Effect in Non-Small Cell Lung Cancer

INTRODUCTION: Estrogen is known to promote proliferation and to activate the epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC). Vascular endothelial growth factor (VEGF) is a known estrogen responsive gene in breast cancer. We sought to determine if the VEGF pathway is al...

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Hauptverfasser: Siegfried, Jill M., Gubish, Christopher T., Rothstein, Mary E., Henry, Cassandra, Stabile, Laura P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288546/
https://ncbi.nlm.nih.gov/pubmed/22258476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e31824177ea
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