BMP2 signals loss of epithelial character in epicardial cells but requires the Type III TGFβ receptor to promote invasion

Coronary vessel development depends on a subpopulation of epicardial cells that undergo epithelial to mesenchymal transformation (EMT) and invade the subepicardial space and myocardium. These cells form the smooth muscle of the vessels and fibroblasts, but the mechanisms that regulate these processe...

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Bibliografiske detaljer
Main Authors: Hill, Cynthia R., Sanchez, Nora S., Love, Joseph D., Arrieta, Julian A., Hong, Charles C., Brown, Christopher B., Austin, Anita F., Barnett, Joey V.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288519/
https://ncbi.nlm.nih.gov/pubmed/22237159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2011.12.022
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