Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions

Myosin IIIA (MYO3A) targets actin protrusion tips using a motility mechanism dependent on both motor and tail actin-binding activity [1]. We show that myosin IIIB (MYO3B) lacks tail actin-binding activity and is unable to target COS7 cell filopodia tips, yet is somehow able to target stereocilia tip...

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Hauptverfasser: Merritt, Raymond C., Manor, Uri, Salles, Felipe T., Grati, M’hamed, Dose, Andrea C., Unrath, William C., Quintero, Omar A., Yengo, Christopher M., Kachar, Bechara
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288355/
https://ncbi.nlm.nih.gov/pubmed/22264607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2011.12.053
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