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The lipoprotein lipase (LPL) S447X gain of function variant involves increased mRNA translation

OBJECTIVE: A common gain-of-function LPL variant, LPLS447X, has favorable clinical features and involves a C→G base change at nucleotide 1595 of the LPL cDNA, along with a haplotype, which includes other non-coding SNPs. The mechanism for the LPL gain-in-function is not clear. LPL translation is reg...

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Main Authors: Ranganathan, Gouri, Unal, Resat, Pokrovskaya, Irina D., Tripathi, Preeti, Rotter, Jerome I., Goodarzi, Mark O., Kern, Philip A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288274/
https://ncbi.nlm.nih.gov/pubmed/22244040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2011.12.028
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