Caricamento...

Novel TIPP (H-Tyr-Tic-Phe-Phe-OH) analogues displaying a wide range of efficacies at the δ opioid receptor. Discovery of two highly potent and selective δ opioid agonists

Analogues of the δ opioid antagonist peptide TIPP (H-Tyr-Tic-Phe-Phe-OH; Tic = 1,2,3,4-tetrahydroisoquinoline3-carboxylic acid) containing various 4′-[N-(alkyl or aralkyl)carboxamido]phenylalanine analogues in place of Tyr(1) were synthesized. The compounds showed subnanomolar or low nanomolar δ opi...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Berezowska, Irena, Lemieux, Carole, Chung, Nga N., Ding, Jinguo, Schiller, Peter W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288262/
https://ncbi.nlm.nih.gov/pubmed/22325949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.01.063
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !