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Cutting Edge: Regulation of TLR4-driven B cell proliferation by RP105 is not B cell-autonomous

Mechanistic understanding of RP105 has been confounded by the fact that this TLR homolog has appeared to have opposing, cell type-specific effects on TLR4 signaling. While RP105 inhibits TLR4-driven signaling in cell lines and myeloid cells, impaired LPS-driven proliferation by B cells from RP105(−/...

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Autori principali: Allen, Jessica L., Flick, Leah M., Divanovic, Senad, Jackson, Shaun W., Bram, Richard, Rawlings, David J., Finkelman, Fred D., Karp, Christopher L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288200/
https://ncbi.nlm.nih.gov/pubmed/22291190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1103282
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