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Syk Inhibition with Fostamatinib Leads to Transitional B Lymphocyte Depletion
Cell signaling initiated by the B cell receptor is critical to normal development of B lymphocytes, most notably at the transitional B cell stage. Inhibition of this signaling pathway with the syk inhibitor, fostamatinib, has produced significant efficacy in lymphoid malignancies and autoimmune cond...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3288165/ https://ncbi.nlm.nih.gov/pubmed/22284392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2011.12.012 |
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