Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia

Certain malignant B cells rely on B-cell receptor (BCR)–mediated survival signals. Spleen tyrosine kinase (Syk) initiates and amplifies the BCR signal. In in vivo analyses of B-cell lymphoma cell lines and primary tumors, Syk inhibition induces apoptosis. These data prompted a phase 1/2 clinical tri...

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Bibliografische gegevens
Hoofdauteurs: Friedberg, Jonathan W., Sharman, Jeff, Sweetenham, John, Johnston, Patrick B., Vose, Julie M., LaCasce, Ann, Schaefer-Cutillo, Julia, De Vos, Sven, Sinha, Rajni, Leonard, John P., Cripe, Larry D., Gregory, Stephanie A., Sterba, Michael P., Lowe, Ann M., Levy, Ronald, Shipp, Margaret A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2010
Onderwerpen:
Clinical Trials and Observations
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852362/
https://ncbi.nlm.nih.gov/pubmed/19965662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-236471
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