Inhibition of Transforming Growth Factor-Activated Kinase 1 (TAK1) Blocks and Reverses Epithelial to Mesenchymal Transition of Mesothelial Cells

Peritoneal fibrosis is a frequent complication of peritoneal dialysis following repeated low grade inflammatory and pro-fibrotic insults. This pathological process may lead to ultrafiltration failure and eventually to the discontinuing of the therapy. Fibrosis is linked to epithelial to mesenchymal...

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Bibliographic Details
Main Authors: Strippoli, Raffaele, Benedicto, Ignacio, Perez Lozano, Maria Luisa, Pellinen, Teijo, Sandoval, Pilar, Lopez-Cabrera, Manuel, del Pozo, Miguel Angel
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288041/
https://ncbi.nlm.nih.gov/pubmed/22384029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031492
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