Brain Deletion of Insulin Receptor Substrate 2 Disrupts Hippocampal Synaptic Plasticity and Metaplasticity

OBJECTIVE: Diabetes mellitus is associated with cognitive deficits and an increased risk of dementia, particularly in the elderly. These deficits and the corresponding neurophysiological structural and functional alterations are linked to both metabolic and vascular changes, related to chronic hyper...

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Main Authors: Costello, Derek A., Claret, Marc, Al-Qassab, Hind, Plattner, Florian, Irvine, Elaine E., Choudhury, Agharul I., Giese, K. Peter, Withers, Dominic J., Pedarzani, Paola
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2012
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287998/
https://ncbi.nlm.nih.gov/pubmed/22383997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031124
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