Do rare variant genotypes predict common variant genotypes?

The synthetic association hypothesis proposes that common genetic variants detectable in genome-wide association studies may reflect the net phenotypic effect of multiple rare polymorphisms distributed broadly within the focal gene rather than, as often assumed, the effect of common functional varia...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kent, Jack W, Farook, Vidya, Göring, Harald HH, Dyer, Thomas D, Almasy, Laura, Duggirala, Ravindranath, Blangero, John
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2011
Pynciau:
Proceedings
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287928/
https://ncbi.nlm.nih.gov/pubmed/22373504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1753-6561-5-S9-S87
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