Do rare variant genotypes predict common variant genotypes?

The synthetic association hypothesis proposes that common genetic variants detectable in genome-wide association studies may reflect the net phenotypic effect of multiple rare polymorphisms distributed broadly within the focal gene rather than, as often assumed, the effect of common functional varia...

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Bibliografiske detaljer
Main Authors: Kent, Jack W, Farook, Vidya, Göring, Harald HH, Dyer, Thomas D, Almasy, Laura, Duggirala, Ravindranath, Blangero, John
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Proceedings
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287928/
https://ncbi.nlm.nih.gov/pubmed/22373504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1753-6561-5-S9-S87
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