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Development, evaluation and application of 3D QSAR Pharmacophore model in the discovery of potential human renin inhibitors
BACKGROUND: Renin has become an attractive target in controlling hypertension because of the high specificity towards its only substrate, angiotensinogen. The conversion of angiotensinogen to angiotensin I is the first and rate-limiting step of renin-angiotensin system and thus designing inhibitors...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3287469/ https://ncbi.nlm.nih.gov/pubmed/22372967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-12-S14-S4 |
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