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Partial deletion of argininosuccinate synthase protects from pyrazole plus lipopolysaccharide-induced liver injury by decreasing nitrosative stress

Argininosuccinate synthase (ASS) is the rate-limiting enzyme in the urea cycle. Along with nitric oxide synthase (NOS)-2, ASS endows cells with the l-citrulline/nitric oxide (NO·) salvage pathway to continually supply l-arginine from l-citrulline for sustained NO· generation. Because of the relevant...

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Bibliografski detalji
Glavni autori: Lu, Yongke, Leung, Tung Ming, Ward, Stephen C., Nieto, Natalia
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287402/
https://ncbi.nlm.nih.gov/pubmed/22052013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00375.2011
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