Mitochondrial uncoupling protein-2 deficiency protects steatotic mouse hepatocytes from hypoxia/reoxygenation

Steatotic livers are sensitive to ischemic events and associated ATP depletion. Hepatocellular necrosis following these events may result from mitochondrial uncoupling protein-2 (UCP2) expression. To test this hypothesis, we developed a model of in vitro steatosis using primary hepatocytes from wild...

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Главные авторы: Evans, Zachary P., Palanisamy, Arun P., Sutter, Alton G., Ellett, Justin D., Ramshesh, Venkat K., Attaway, Hubert, Schmidt, Michael G., Schnellmann, Rick G., Chavin, Kenneth D.
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2012
Предметы:
Liver and Biliary Tract
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287401/
https://ncbi.nlm.nih.gov/pubmed/22094601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00049.2011
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