Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer

Trastuzumab, a monoclonal antibody targeting human epidermal growth factor receptor 2 (HER2; also known as HER-2/neu), is indicated for the treatment of women with either early stage or metastatic HER2(+) breast cancer. It kills tumor cells by several mechanisms, including antibody-dependent cellula...

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Main Authors: Kohrt, Holbrook E., Houot, Roch, Weiskopf, Kipp, Goldstein, Matthew J., Scheeren, Ferenc, Czerwinski, Debra, Colevas, A. Dimitrios, Weng, Wen-Kai, Clarke, Michael F., Carlson, Robert W., Stockdale, Frank E., Mollick, Joseph A., Chen, Lieping, Levy, Ronald
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287235/
https://ncbi.nlm.nih.gov/pubmed/22326955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61226
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