Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma

Glioblastoma (GBM), a uniformly lethal brain cancer, is characterized by diffuse invasion and abnormal activation of multiple receptor tyrosine kinase (RTK) signaling pathways, presenting a major challenge to effective therapy. The activation of many RTK pathways is regulated by extracellular hepara...

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Detalhes bibliográficos
Main Authors: Phillips, Joanna J., Huillard, Emmanuelle, Robinson, Aaron E., Ward, Anna, Lum, David H., Polley, Mei-Yin, Rosen, Steven D., Rowitch, David H., Werb, Zena
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287216/
https://ncbi.nlm.nih.gov/pubmed/22293178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI58215
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