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Association of antisense oligonucleotides with lipoproteins prolongs the plasma half-life and modifies the tissue distribution.

In order to direct antisense oligonucleotides to specific tissues or cell types in vivo, we are exploring the possibility to utilize lipoproteins as transport vehicles. A 16-mer oligonucleotide (ODN) was derivatized at the 5' prime through a 32P phosphate spacer with cholesterol, yielding a 32P...

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Detalhes bibliográficos
Main Authors: de Smidt, P C, Le Doan, T, de Falco, S, van Berkel, T J
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC328711/
https://ncbi.nlm.nih.gov/pubmed/1891360
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