Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response

Selective small-molecule inhibitors represent powerful tools for the dissection of complex biological processes. ES(I) (eeyarestatin I) is a novel modulator of ER (endoplasmic reticulum) function. In the present study, we show that in addition to acutely inhibiting ERAD (ER-associated degradation),...

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Main Authors: McKibbin, Craig, Mares, Alina, Piacenti, Michela, Williams, Helen, Roboti, Peristera, Puumalainen, Marjo, Callan, Anna C., Lesiak-Mieczkowska, Karolina, Linder, Stig, Harant, Hanna, High, Stephen, Flitsch, Sabine L., Whitehead, Roger C., Swanton, Eileithyia
Format: Artigo
Sprog:Inglês
Udgivet: Portland Press Ltd. 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286858/
https://ncbi.nlm.nih.gov/pubmed/22145777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20111220
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