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Robust EM Continual Reassessment Method in Oncology Dose Finding
The continual reassessment method (CRM) is a commonly used dose-finding design for phase I clinical trials. Practical applications of this method have been restricted by two limitations: (1) the requirement that the toxicity outcome needs to be observed shortly after the initiation of the treatment;...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3286608/ https://ncbi.nlm.nih.gov/pubmed/22375092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1198/jasa.2011.ap09476 |
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