Anti-Idiotypic Antibody Specific to GAD65 Autoantibody Prevents Type 1 Diabetes in the NOD Mouse

Overt autoantibodies to the smaller isoform of glutamate decarboxylase (GAD65Ab) are a characteristic in patients with Type 1 diabetes (T1D). Anti-idiotypic antibodies (anti-Id) directed to GAD65Ab effectively prevent the binding of GAD65 to GAD65Ab in healthy individuals. Levels of GAD65Ab-specific...

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Autors principals: Wang, Xin, Zhang, Aixia, Liu, Yu, Chen, Shi, Feng, Zhenqing, Shang, Wenbin, Maziarz, Marlena, Radtke, Jared, Hampe, Christiane S.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286479/
https://ncbi.nlm.nih.gov/pubmed/22384267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032515
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