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Modulation of diabetes in NOD mice by GAD65-specific monoclonal antibodies is epitope specific and accompanied by anti-idiotypic antibodies

Type 1 diabetes is caused by the autoimmune destruction of pancreatic beta cells. Here we show that administration of a human monoclonal antibody (b96·11) specific to the 65-kDa isoform of glutamate decarboxylase (GAD65) to prediabetic non-obese diabetic (NOD) mice significantly delays the onset of...

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Détails bibliographiques
Auteurs principaux: Hall, Tyler R, Bogdani, Marika, LeBoeuf, Renee C, Kirk, Elizabeth A, Maziarz, Marlena, Banga, J Paul, Oak, Shilpa, Pennington, Christina A, Hampe, Christiane S
Format: Artigo
Langue:Inglês
Publié: Blackwell Science Inc 2008
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2433323/
https://ncbi.nlm.nih.gov/pubmed/18005036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2007.02724.x
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