Heteromeric Canonical Transient Receptor Potential 1 and 4 Channels Play a Critical Role in Epileptiform Burst Firing and Seizure-Induced Neurodegeneration

Canonical transient receptor potential channels (TRPCs) are receptor-operated cation channels that are activated in response to phospholipase C signaling. Although TRPC1 is ubiquitously expressed in the brain, TRPC4 expression is the most restrictive, with the highest expression level limited to the...

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Hauptverfasser: Phelan, Kevin D., Mock, Matthew M., Kretz, Oliver, Shwe, U. Thaung, Kozhemyakin, Maxim, Greenfield, L. John, Dietrich, Alexander, Birnbaumer, Lutz, Freichel, Marc, Flockerzi, Veit, Zheng, Fang
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2012
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286301/
https://ncbi.nlm.nih.gov/pubmed/22144671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.075341
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