Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy

AIMS: Insulin-like growth factor 1 (IGF-1) is known to exert cardioprotective actions. However, it remains unknown if autophagy, a major adaptive response to nutritional stress, contributes to IGF-1-mediated cardioprotection. METHODS AND RESULTS: We subjected cultured neonatal rat cardiomyocytes, as...

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主要な著者: Troncoso, Rodrigo, Vicencio, Jose Miguel, Parra, Valentina, Nemchenko, Andriy, Kawashima, Yuki, del Campo, Andrea, Toro, Barbra, Battiprolu, Pavan K., Aranguiz, Pablo, Chiong, Mario, Yakar, Shoshana, Gillette, Thomas G., Hill, Joseph A., Abel, Evan Dale, LeRoith, Derek, Lavandero, Sergio
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2012
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Original Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286200/
https://ncbi.nlm.nih.gov/pubmed/22135164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvr321
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