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Transcriptional profiling of the age-related response to genotoxic stress points to differential DNA damage response with age

The p53 DNA damage response attenuated with age and we have evaluated downstream factors in the DNA damage response. In old animals p21 protein accumulates in the whole cell fraction but significantly declines in the nucleus, which may alter cell cycle and apoptotic programs in response to DNA damag...

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Detalhes bibliográficos
Main Authors: Simon, Kirk, Mukundan, Anju, Dewundara, Samantha, Van Remmen, Holly, Dombkowski, Alan A., Cabelof, Diane C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285901/
https://ncbi.nlm.nih.gov/pubmed/19679149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2009.07.007
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